Professor Paulo Ferreira is a world leader in the design, implementation and analysis of clinical trials, systematic reviews and observational studies in musculoskeletal pain. He has published >350 manuscripts including 21 randomised controlled trials. His clinical trials include a variety of designs including placebo medication trials, digital health trials, lifestyle programs, implementation trials, cluster, and adaptive platform trial designs. His trials and clinical work have been cited >30,000 times across 113 countries and 27 disciplines, placing it in the top 0.03% most influential low back pain programs programs internationally. He is one of the world leaders in the field of low back pain. His research interests also expand to the field of genetics, eHealth, and lifestyle in chronic pain. He is a Professor at the Faculty of Medicine and Health, Director of the Musculoskeletal Research Hub at the Charles Perkins Centre, and Research Academic Director at the University of Sydney. He is also a CI on a NHMRC Centre for Research Excellence on Twin Research, and was the top NHMRC Research Fellow (Industry Category 2018-2021). He has been given grant support of >$15M, including NHMRC and MRFF projects, Fellowships, equipment, and CRE grant. Professor Paulo Ferreira has published in leading journals such as The Lancet, BMJ, and Annals of Internal Medicine. He is the world’s most published researcher in low back pain and physical activity. He is one of the leaders of the Senior Editorial Group that led a 2018 Lancet series on back pain. His research has shifted how low back pain is managed through lifestyle management, and the impact has attracted media attention nationally and internationally (e.g. SBS News, Sydney Morning Herald, CNN USA, NY Times, Times UK, Le Figaro France), and informed >19 low back pain guidelines worldwide. He is currently implementing the first National Help Line for low back pain in a large NHMRC partnership funded project ($3.3M).